OPEN CALLS
POSTDOCTORAL POSITION
within the scope of the project ERC-2020-COG ChromoSilence- 101002391, entitled: “Chromosome-based mechanisms of transcriptional inactivation during mitosis”
within the scope of the project ERC-2020-COG ChromoSilence- 101002391, entitled: “Chromosome-based mechanisms of transcriptional inactivation during mitosis”
Have you ever wondered... what is the purpose of transcriptional shutdown upon mitotic entry in higher eukaryotes?
Mitotic Transcriptional Inactivation (MTI) is commonly seen as a simple by-product of the chromosome rearrangements that occur on chromatin upon mitotic entry, serving no other purpose to the cell. Our recently awarded ERC project -ChromoSilence - aims to challenge this dogma and build on the hypothesis that MTI is a vital mechanism to ensure proper nuclear division and maintenance of transcriptional programs, with direct consequences on cell physiology, tissue homeostasis and, ultimately, organism development.
Do you want to join the team?
Eligibility / Requirements: We are seeking a highly motivated and ambitious candidate with a PhD in Biology/ Biochemistry/ Biophysics or related areas. Solid expertise in Drosophila development/human cell culture and/or genome-wide transcriptional analysis, although not essential, will be considered an advantage. We expect the candidate to drive her/his project with a high degree of independence but within the open-minded collaborative atmosphere of the lab. Good communication skills, including a good level of spoken English are necessary.
Functions to be performed/Workplan: The selected candidate will join the Chromosome Dynamics Laboratory in April 2022 (flexible). Research in the lab aims at understanding how chromosomes are assembled and how their morphology influences the fidelity of cell division. Successful candidates will join an ERC-funded team (ERC-2020-COG-ChromoSilence- 101002391). The successful candidate will focus on studying the consequences of failures in mitotic transcription inactivation (MTI). Specific tasks include: 1) analysis of transcriptional outputs using genome-wide approaches to monitor ongoing transcription; 2) analysis of developmental consequences upon failures of specific candidates.
Further details on the type of contract and salary can be found on the following links (according to the Portuguese law, contract type/conditions differ depending on time after awarded PhD):
PhD holder <3 years or PhD holder > 3 years
Selection methods: Applications will be evaluated according to the Curriculum and reference letters (60%), and motivation letter (20%). If considered necessary by the jury, the interview of shortlisted candidates will represent 20% of the final mark. The final results will be expressed in a scale of 0-100. The deliberation is made by means of nominal vote, according to the eligibility and selection criteria, and abstentions are not allowed.
How to apply: Applications must be submitted from 9th February until 16th March of 2022. Applications must include a Letter of Motivation and Curriculum Vitae sent by the candidate and 2 reference letters sent by the referees. Applications and reference letters should be sent independently by e-mail to rcoliveira@igc.gulbenkian.pt, with the subject “ERC Post-Doctoral position”. The applications single pdf file should be named “CandidateName_ERCproject2022.pdf”.
Mitotic Transcriptional Inactivation (MTI) is commonly seen as a simple by-product of the chromosome rearrangements that occur on chromatin upon mitotic entry, serving no other purpose to the cell. Our recently awarded ERC project -ChromoSilence - aims to challenge this dogma and build on the hypothesis that MTI is a vital mechanism to ensure proper nuclear division and maintenance of transcriptional programs, with direct consequences on cell physiology, tissue homeostasis and, ultimately, organism development.
Do you want to join the team?
Eligibility / Requirements: We are seeking a highly motivated and ambitious candidate with a PhD in Biology/ Biochemistry/ Biophysics or related areas. Solid expertise in Drosophila development/human cell culture and/or genome-wide transcriptional analysis, although not essential, will be considered an advantage. We expect the candidate to drive her/his project with a high degree of independence but within the open-minded collaborative atmosphere of the lab. Good communication skills, including a good level of spoken English are necessary.
Functions to be performed/Workplan: The selected candidate will join the Chromosome Dynamics Laboratory in April 2022 (flexible). Research in the lab aims at understanding how chromosomes are assembled and how their morphology influences the fidelity of cell division. Successful candidates will join an ERC-funded team (ERC-2020-COG-ChromoSilence- 101002391). The successful candidate will focus on studying the consequences of failures in mitotic transcription inactivation (MTI). Specific tasks include: 1) analysis of transcriptional outputs using genome-wide approaches to monitor ongoing transcription; 2) analysis of developmental consequences upon failures of specific candidates.
Further details on the type of contract and salary can be found on the following links (according to the Portuguese law, contract type/conditions differ depending on time after awarded PhD):
PhD holder <3 years or PhD holder > 3 years
Selection methods: Applications will be evaluated according to the Curriculum and reference letters (60%), and motivation letter (20%). If considered necessary by the jury, the interview of shortlisted candidates will represent 20% of the final mark. The final results will be expressed in a scale of 0-100. The deliberation is made by means of nominal vote, according to the eligibility and selection criteria, and abstentions are not allowed.
How to apply: Applications must be submitted from 9th February until 16th March of 2022. Applications must include a Letter of Motivation and Curriculum Vitae sent by the candidate and 2 reference letters sent by the referees. Applications and reference letters should be sent independently by e-mail to rcoliveira@igc.gulbenkian.pt, with the subject “ERC Post-Doctoral position”. The applications single pdf file should be named “CandidateName_ERCproject2022.pdf”.