Welcome to the chromosome dynamics lab
The Chromosome Dynamics Lab, at Instituto Gulbenkian de Ciência, studies how chromosome architecture contributes to faithful genome segregation. Genome stability relies on the fact that at each round of cell division, the genetic information encoded in the DNA molecules is properly segregated into the two daughter cells. Proper completion of this process, in turn, depends on major changes in chromosome organisation including cohesion between the two identical DNA molecules (sister chromatids) and condensation of the long DNA fibbers. We aim to dissect how mitotic chromosomes are assembled and how their physical properties contribute to faithful cell division.
By studying the contribution of chromosome structure in the mechanics of nuclear division we aim to identify novel routes to aneuploidy that underlie several human conditions, including developmental diseases, cancer and infertility.
Read more about our research.
see also CHR in the news
Post-doc position available in our lab.
Check more details here.
Ewa Piskadlo's great work on chromosome structure and resolution is now out!